Ischemic stroke after covid-19 mRNA vaccination (Pfizer): A case report

COVID-19 has been linked to more than expected cases of strokes especially in young population. Over a 42-day follow-up period, the BNT162b2 vaccination caused few side effects, majority of it were minors and few are dangerous. This is the second case report which suggest a relationship between COVID-19 mRNA BNT162b2 (Pfizer) vaccine and stroke. Our case is regarding 40-year Saudi women previously healthy, presented to ER with signs and symptoms of weakness in her right side with ipsilateral mild facial palsy and slurred speech ten days after receiving first dose BNT162b2 vaccine. Non-contrast CT scan of the brain demonstrated large fairly defined hypodense area involving the left fronto-temporal region;it exerts a mass effect in the form of effacement in the cortical sulci and mild compression of the ipsilateral ventricle with no shift of the midline structures. In our case, a link between the stroke and Pfizer vaccine is hard to exclude out. The above link has to be investigated further, and people who develop a stroke sooner after getting the first dose should be addressed carefully.

COVID-19 protease inhibitor using Azole N-Mannich bases: A molecular docking approach

Coronaviruses are the largest group of viruses belonging to the Nidovirales order, which includes Coronaviridae, Arteriviridae and Roniviridae families. In this work, a molecular modeling technique is adopted to find out the excellent moiety to inhibit the protease enzyme which is present in the coronavirus. Autodock 4.2 tool was used to find out the docking score of 32 ligands. The molinspiration server helps to find out the drug-likeness property and whether these ligands having a binding towards the protease enzyme. The synthetic N-Mannich bases of azole were docked with COVID-19 main protease in complex with an inhibitor N3 (PDB id: 6lu7). Among 32 ligand molecules, around 25 ligands showed an excellent binding score when compared to the standard drug favipiravir. The presence of dimethyl group in the pyrazole nucleus helps good interaction with protease enzyme. Among the Mannich bases, the secondary amine mannich base of piperazine considered as the best derivative to inhibit the protease enzyme. © 2021 Chemical Publishing Co.. All rights reserved.